Pulmozyme is contraindicated in patients with hypersensitivity to dornase alfa, Chinese Hamster Ovary (CHO) cell products, or formulation excipients.

Hypersensitivity, Storage, and Device-Specific Guidance

Key precautions include strict adherence to nebulizer compatibility (e.g., avoiding masks with eRapid® for pediatric patients) and avoiding drug mixing. Storage mandates refrigeration (2°C–8°C) in protective foil; exposure to room temperature >60 hours invalidates use. Pediatric safety is established for ages ≥3 months, but geriatric data are lacking. No warnings for drug interactions or teratogenicity exist, though pregnancy/lactation data remain limited. Device maintenance (cleaning, disinfection) per manufacturer guidelines is critical to prevent contamination.