Precautions for ALDURAZYME® include monitoring for hypersensitivity reactions, respiratory complications, and infusion-related adverse events.

Precautions for ALDURAZYME® Administration

Patients receiving ALDURAZYME® should be closely monitored for hypersensitivity reactions, including anaphylaxis, during and after infusion. Appropriate emergency medical equipment, such as cardiopulmonary resuscitation tools, should be available. Infusion-related reactions (IARs) such as fever, chills, or changes in blood pressure are common and may require dose adjustment or premedication with antihistamines. Patients with respiratory conditions, including sleep apnea or compromised lung function, need extra monitoring, as infusion reactions could exacerbate their condition. In these cases, respiratory support should be available during administration. Patients with fluid overload risks may require reduced infusion volumes and rates.