Fostemsavir is a novel antiretroviral drug. As an HIV-1 gp120-directed attachment inhibitor, it provides an important treatment option for patients with multiply drug-resistant HIV-1 infection.
Indications for Fostemsavir
Target Patient Population
It is indicated for adult patients with extensive treatment experience who have failed their current antiretroviral regimens due to drug resistance, intolerance, or safety issues.
Requirements for Combined Medication
It must be used in combination with other antiretroviral drugs and shall not be used alone.
Its mechanism of action is to inhibit the binding of the gp120 protein on the surface of the HIV-1 virus to host cells, thereby blocking the virus attachment process.
Specifications and Characteristics of Fostemsavir
Dosage Form and Strength
Fostemsavir is supplied as 600 mg extended-release tablets, with each tablet containing the active ingredient fostemsavir tromethamine (equivalent to 725 mg).
Appearance Characteristics
The tablets are beige, oval, film-coated, and have a biconvex design.
One side is engraved with the marking "SV1V7" for easy identification.
Ingredient Description
In addition to the active ingredient, excipients include colloidal silicon dioxide, hydroxypropyl cellulose, etc. The film coating contains inactive ingredients such as iron oxide red/yellow, polyethylene glycol, etc.
Storage Method for Fostemsavir
Routine Storage Conditions
It should be stored at room temperature (20°C–25°C), and short-term storage in an environment of 15°C–30°C is permitted.
Avoid moisture or direct sunlight, and keep it in the original packaging to prevent moisture absorption.
Special Precautions
The tablets should be swallowed whole and shall not be chewed, crushed, or split, so as not to destroy the extended-release structure.
Keep it out of the reach of children to prevent accidental ingestion.
Stability Description
The drug has good stability in unopened packaging and does not require refrigeration, but the expiration date should be checked regularly.
