Caplacizumab is a specific drug for the treatment of acquired thrombotic thrombocytopenic purpura (aTTP) in adults, manufactured by the French company Sanofi. Since this drug has not yet been launched in China, patients need to purchase authentic products through specific channels. Then, what are the precautions for using Caplacizumab?
Precautions for Using Caplacizumab
Standardized medication is crucial for ensuring therapeutic efficacy and reducing risks. As an antiplatelet drug, Caplacizumab requires special medication management.
Pre-Treatment Evaluation
Before using the drug, it is necessary to complete platelet count, ADAMTS13 activity testing, and coagulation function examination.
Assess bleeding risk factors, including a history of previous bleeding, concurrent medications, etc.
Women of childbearing age must confirm that they are not pregnant and need to take reliable contraceptive measures during treatment.
Injection Technique Requirements
The first dose must be administered intravenously by medical staff. Subsequent subcutaneous injections can be given in the abdomen (at least 5 cm away from the umbilicus), thighs, or upper arms.
Allow the drug solution to return to room temperature before injection, and apply pressure to the injection site for 5 minutes after injection.
Rotate injection sites and avoid repeated injections in the same area.
Use a dedicated sharps container to dispose of used needles.
Adverse Reaction Monitoring
Establish a medication diary to record the time, site of each injection, and physical reactions.
Closely monitor for bleeding symptoms; if a nosebleed lasts for more than 10 minutes or hematuria occurs, seek medical attention immediately.
Regularly recheck platelet count and coagulation function, generally 1-2 times a week.
Authentic Purchase Channels for Caplacizumab
Ensuring a formal source of the drug is the primary condition for safe treatment. Caplacizumab is a prescription drug and needs to be obtained through professional medical channels.
Procurement through Cooperation with International Hospitals
Some domestic hospitals have cooperative programs with Sanofi-authorized medical institutions, which can assist patients in purchasing the drug from formal channels in Europe.
Sanofi Officially Authorized Pharmacies
Sanofi has an authorized pharmacy network in various EU countries. Patients can inquire about the nearest authorized pharmacy through the official website.
Cross-Border Medical Service Institutions
Professional cross-border medical intermediaries can assist patients in contacting specialized hospitals in Europe for medical treatment and obtaining prescriptions. This method is suitable for patients who need to adjust their treatment plans; a medical team will follow up throughout the process, and the drug can be purchased directly from the hospital pharmacy.
Dietary Precautions for Caplacizumab
Reasonable dietary management helps reduce the risk of bleeding and improve treatment effects. Special nutritional adjustments are required during the medication period.
Foods Affecting Coagulation
Limit the intake of foods rich in vitamin K (such as spinach, broccoli) to no more than 100 grams per day.
Avoid excessive consumption of condiments that may affect coagulation, such as garlic and ginger.
Control alcohol intake: no more than 2 standard drinks per day for men and no more than 1 standard drink per day for women. (Note: A "standard drink" typically refers to a beverage containing approximately 10-15 grams of pure alcohol, with specific standards varying slightly by region.)
Nutritional Supplement Recommendations
Appropriately increase the intake of foods rich in vitamin C (such as citrus fruits, bell peppers) to enhance blood vessel elasticity.
The daily protein intake should be 1.2-1.5 grams per kilogram of body weight, with priority given to fish, poultry, and soy products.
Maintain daily water intake at 2000-2500 milliliters, distributed evenly throughout the day.
Record daily dietary intake, including the type, quantity of food, and physical reactions.
Conduct regular nutritional assessments and consult a clinical dietitian to adjust the diet plan if necessary.
