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   How much does Defitelio cost per box?
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Aug 21, 2025
Defibrotide is a mixture of single-stranded oligonucleotides derived from the genomic DNA of calf lung or porcine intestinal mucosa. It is indicated for adult and pediatric patients with hepatic veno-occlusive disease (VOD) accompanied by renal or pulmonary dysfunction after hematopoietic stem cell transplantation.

How much does Defitelio cost per box?

The specific price of defibrotide may vary depending on factors such as purchasing channels, drug specifications, and promotional activities.

Patients can search for defibrotide on online pharmacies. It is essential to choose legal and reliable online pharmacies and abide by relevant laws and regulations. Patients can also consider purchasing through regular overseas channels, but this requires careful identification to avoid buying counterfeit or shoddy products.

Precautions for Defibrotide

During the use of defibrotide, special attention should be paid to two aspects: bleeding and allergic reactions:

Bleeding

Monitoring bleeding: During the use of defibrotide, patients should closely monitor for bleeding tendencies. Defibrotide works by inhibiting plasminogen activators, reducing fibrinolysis to achieve hemostasis, but it may increase the risk of bleeding.

Handling bleeding events: Once patients notice a bleeding tendency or bleeding has occurred, they should immediately stop the infusion of defibrotide and take corresponding hemostatic measures.

Allergic Reactions

Monitoring allergic reactions: Before using defibrotide, patients should inform the doctor in detail about their allergy history, especially allergies to drug components. During use, patients need to closely observe for symptoms of allergic reactions.

Handling allergic reactions: Once a patient experiences an allergic reaction, the infusion of defibrotide should be stopped immediately, and treatment should be given according to standard care.

Other Precautions

Dosage and frequency: The recommended dose for adult and pediatric patients is 6.25mg/kg per dose, once every 6 hours. The infusion time should not be less than 2 hours, and the treatment should last for at least 21 days.

How to store Defibrotide?

The storage method of defibrotide requires special attention, and the specific storage recommendations are as follows:

Storage Temperature

The standard storage temperature for defibrotide is 20°C - 25°C, and storage between 15°C and 30°C is allowed.

Storage Location

Defibrotide should be stored in a cool and dry place, away from direct sunlight, as direct sunlight may cause the drug to deteriorate or become ineffective.

Package Sealing

The packaging of defibrotide should be tightly sealed to prevent moisture intrusion, which may affect product quality. Defibrotide injections are usually contained in clear glass vials for single-patient use, and these containers should remain sealed.

Warm reminder: Defibrotide is a drug used for the treatment of specific diseases. Patients should fully understand information such as its indications, usage, dosage, and precautions before using it.

Note: For internal discussion among medical personnel only. For specific medication, please consult the attending physician. Drug information may change over time. For the latest information, we recommend adding a medical consultant or consulting for free online.
Defibrotide(Defitelio)
diagnosed with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), in the setting of hematopoietic stem-cell transplantation (HSCT).
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