Thyrogen (Thyrotropin α for injection) is a recombinant human thyroid-stimulating hormone (rhTSH) that is widely used in the diagnosis and treatment of thyroid diseases. For patients who are concerned about this drug, it is particularly important to understand its effects, precautions for use and adverse reactions.
How effective is Thyrogen (Thyrotropin α for injection)?
Thyrogen is mainly used for the auxiliary diagnosis and treatment of thyroid lesions, and its effect has been verified in clinical applications.
Indications and efficacy
Thyrogen's indications include auxiliary diagnosis of well-differentiated thyroid lesions, auxiliary treatment of thyroid remnant ablation, and serum thyroglobulin (Tg) detection.
It can stimulate thyroid lesion cells to take up radioactive iodine by simulating TSH (thyroid-stimulating hormone) secreted by the human pituitary gland, thereby enhancing the killing effect of radioactive iodine on residual thyroid tissue and metastatic lesions. Thyrogen can also stimulate the secretion of thyroglobulin and improve the sensitivity and accuracy of detection.
In clinical trials, Thyrogen has shown significant efficacy, can increase the sensitivity of thyroglobulin, and help doctors diagnose thyroid diseases more accurately.
Mechanism of Action
The mechanism of action of Thyrogen is that it can simulate the TSH secreted by the pituitary gland under natural conditions and induce the thyroid gland to release thyroid hormone.
Before patients with differentiated thyroid lesions (DTC) receive radioactive iodine treatment, the TSH level in the body needs to be increased to stimulate the uptake of radioactive iodine by thyroid lesion cells.
Thyrogen can exogenously increase TSH levels to avoid hypothyroidism symptoms caused by discontinuation of thyroid hormone replacement therapy. In addition, TSH can stimulate thyroid lesion cells to secrete Tg. Thyrogen increases serum Tg levels by increasing TSH levels, thereby more sensitively detecting possible micro-residual lesions or recurrent metastatic lesions.
Understanding the effects of Thyrogen can help patients better understand the role of this drug in the treatment of thyroid diseases. Before using Thyrogen, patients must consult a doctor and undergo a comprehensive physical examination.
What should be noted when using thyroid stimulating hormone alpha?
When using Thyrogen, patients need to pay attention to the following matters.
Contraindications and population of users
Thyrogen is contraindicated for patients who are allergic to bovine or human thyroid stimulating hormone or any excipients, pregnant women and lactating women. Patients with a history of heart disease or significant thyroid residual tissue should use it with caution. Thyrogen is not recommended for use after stopping radiotherapy due to thyroid lesions.
Dosage and storage conditions
Thyrogen can only be injected intramuscularly, and patients cannot change the usage without authorization. It needs to be diluted before use. If it cannot be used in time, the diluted injection can be placed for 24 hours at a temperature of 2-8°C if necessary. When storing, Thyrogen should be placed in a dark, dry place out of the reach of children.
Mastering the precautions for the use of thyroid stimulating hormone α can help patients avoid unnecessary medication risks.
Adverse reactions of thyroid stimulating hormone α
Although Thyrogen has shown significant efficacy in clinical trials, it may still cause some adverse reactions. Understanding these adverse reactions can help patients respond in time.
Common adverse reactions
The most common adverse reactions reported in clinical trials are nausea and headache, which are acceptable to most patients. These symptoms are usually temporary and will not affect the treatment effect.
Serious adverse reactions
Although no other adverse reactions were found, patients still need to pay close attention to their physical reactions. If other discomfort or symptoms occur, they should seek medical attention in time and follow the doctor's advice to make adjustments.
Thyrogen's unique pharmacological properties and potential side effects also require patients to have correct medication knowledge. Before using Thyrogen, patients must consult a doctor and undergo a comprehensive physical examination. During the medication period, patients should follow the doctor's instructions, take the medication on time and in the right amount, and closely monitor their physical reactions. If any discomfort or questions occur, they should seek medical attention in time and follow the doctor's advice to make adjustments.
