Duvyzat (Givinostat) is a new drug for the treatment of Duchenne muscular dystrophy (DMD). Its unique non-steroidal properties and effectiveness for all genetic variant DMD patients make it the focus of attention of many patients and their families.
How to buy Duvyzat
Since Duvyzat has not yet been launched in China, domestic patients need to obtain the drug through specific channels.
Spanish ItalfarmacoS.p.A. version of Duvyzat
Currently, the main way is to import directly from Spanish ItalfarmacoS.p.A., with a specification of 140ml per box. Considering the high price and complex procurement process, it is recommended that patients or their families cooperate with professional pharmaceutical consulting companies to obtain the required drugs more conveniently.
When looking for a reliable purchase channel, in addition to considering the authenticity of the source of the drug, it is also necessary to pay attention to the temperature control in the logistics process and make it clear that the drug remains stable during transportation.
Duvyzat purchase precautions
Understanding the purchase precautions of the drug can help to promptly discover and deal with possible problems, thereby maintaining the safety of treatment.
Pre-start evaluation and testing
Before starting Duvyzat, a comprehensive medical evaluation must be performed, including platelet count, serum triglyceride level, and electrocardiogram. These preliminary preparations not only help determine whether you are suitable for treatment, but also provide a basis for subsequent dose adjustments.
Special population medication instructions
Duvyzat should be used with extreme caution and under the guidance of a professional physician for pregnant women, lactating women, men and women of reproductive potential, and patients with renal or hepatic impairment. Although research data on these groups is limited, preliminary studies have shown that there may be certain risks.
Following the doctor's advice and making individualized dose adjustments and close monitoring can minimize potential risks and provide patients with the best treatment plan.
Dietary structure of patients taking Duvyzat
Understanding the following article can help patients better plan their daily diet to cooperate with drug treatment and achieve better treatment effects.
High-fat meals and drug absorption
Studies have shown that taking Duvyzat with a high-fat meal can increase the drug exposure (AUC) of Duvyzat by about 40%, increase the peak concentration (Cmax) by about 23%, and delay Tmax. This means that a reasonable diet, especially choosing foods containing an appropriate amount of fat, may help improve the efficacy of the drug.
Management of abnormal lipid metabolism
The use of Duvyzat may lead to an increase in serum triglycerides, with some patients testing values exceeding 300 mg/dL. Therefore, special attention should be paid to lipid metabolism during treatment, and dietary intervention measures should be taken when necessary, such as reducing saturated fatty acid intake and increasing the proportion of dietary fiber.
A reasonable diet structure not only helps control abnormal lipid metabolism, but also improves overall health and supports the optimal efficacy of Duvyzat.
