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   What are the adverse reactions of taking trabectedin (YONDELIS)?
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Jul 08, 2025

Trabectedin (YONDELIS) is a therapeutic drug for specific sarcomas. It has shown unique efficacy in clinical applications, but it is also accompanied by a series of adverse reactions. So, what are the adverse reactions of taking trabectedin (YONDELIS)?

What are the adverse reactions of taking trabectedin (YONDELIS)?

Trabectedin is a cytotoxic drug, which may cause a variety of adverse reactions during treatment, posing a challenge to the patient's quality of life and treatment continuity.

Common adverse reactions

After taking trabectedin, the most common adverse reactions in patients include digestive system symptoms such as nausea, fatigue, vomiting, constipation, decreased appetite, diarrhea, and systemic symptoms such as peripheral edema, dyspnea and headache. Laboratory tests may also reveal blood system abnormalities such as neutropenia, thrombocytopenia, and anemia.

Serious adverse reactions

In addition, trabectedin may also cause some serious adverse reactions, such as liver failure caused by hepatotoxicity, heart failure caused by cardiomyopathy, rhabdomyolysis, and capillary leak syndrome. These adverse reactions require immediate medical treatment.

It is important for patients and doctors to understand the adverse reactions of trabectedin so that timely measures can be taken to alleviate symptoms and ensure the safety of treatment.

Methods to alleviate adverse reactions after taking trabectedin (YONDELIS)

Taking effective mitigation measures for the adverse reactions of trabectedin can improve patients' tolerance and quality of life.

Drug adjustment and monitoring

For patients with adverse reactions, doctors should adjust the drug dosage or suspend the administration according to the specific situation, and conduct blood and liver function tests regularly to detect and deal with abnormal conditions in time.

Supportive treatment

Supportive treatment is also an important means to alleviate adverse reactions, including symptomatic treatment such as antiemetics and antidiarrheal drugs, as well as improving the overall condition of patients through nutritional support, psychological intervention, etc.

Through drug adjustment, monitoring and supportive treatment, the adverse reactions of trabectedin can be effectively alleviated, and the patient's treatment experience and effect can be improved.

Eating habits of patients with trabectedin (YONDELIS)

Good eating habits are important for patients with trabectedin, which helps to reduce adverse reactions and improve body resistance.

Balanced nutrition

Patients should maintain a balanced nutritional intake and eat more foods rich in protein, vitamins and minerals, such as lean meat, fish, vegetables, fruits, etc. At the same time, avoid consuming too much greasy, spicy and irritating food to avoid adding burden to the digestive system.

Light and easy to digest

During treatment, patients should choose light and easy to digest foods, such as porridge, noodles, steamed eggs, etc. These foods are easy to digest and absorb, and help relieve gastrointestinal discomfort.

By maintaining a balanced nutrition and choosing light and easy to digest foods, patients with trabectedin can better cope with the challenges during treatment and improve their quality of life.

Note: For internal discussion among medical personnel only. For specific medication, please consult the attending physician. Drug information may change over time. For the latest information, we recommend adding a medical consultant or consulting for free online.
Trabectedin(YONDELIS)
It is indicated for the treatment of unresectable or metastatic liposarcoma or leiomyosarcoma in patients who have previously received anthracycline-based therapy.
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