Trabectedin can bind to guanine residues in the minor groove of DNA to form adducts, causing DNA helix bending. This adduct can affect and inhibit protein synthesis, interfere with the cell cycle, and inhibit cell division and proliferation at the genetic level.
Usage and dosage of trabectedin
The usage and dosage of trabectedin should be determined according to the patient's condition and treatment plan. The following content will introduce the specific usage in detail.
Recommended dose and administration cycle
The standard recommended dose of trabectedin is 1.5mg/m², which is infused through the central vein once every 21 days for 24 hours each time. This interval administration method helps to reduce the burden on the body and enable the drug to achieve the best effect in the body. For patients with impaired liver function, the dose needs to be adjusted according to the specific situation to reduce the risk of toxicity. For example, the dose for patients with moderate liver function impairment should be reduced to 0.9mg/m².
Dosage adjustment for special populations
Pregnant women, lactating women and children and other special populations should be particularly cautious in the use of drugs. At present, the safety and efficacy of trabectedin in children have not been fully verified, so it needs to be used with caution under the guidance of a doctor.
The usage and dosage of trabectedin embodies the concept of individualized treatment. Next, we will further explore the matters that need to be paid attention to when using this drug.
Is there anything to pay attention to when using trabectedin?
In order to maximize the efficacy of trabectedin and reduce the occurrence of adverse reactions, patients need to pay attention to multiple aspects during use.
Preventing infusion-related reactions
Before infusing trabectedin, patients need to take dexamethasone and other drugs as pretreatment to reduce the risk of infusion-related reactions. During the infusion, vital signs should be closely monitored. If symptoms such as fever, chills or hypotension occur, the infusion should be interrupted immediately and appropriate measures should be taken. During the infusion, an infusion set with a 0.2-micron polyethersulfone (PES) in-line filter should be used to reduce the risk of pathogens that may be introduced during the preparation of the contact solution.
Monitoring liver function and blood indicators
Trabectedin may cause abnormal liver function and hematological toxicity, so patients need to regularly check liver function indicators (such as ALT, AST, total bilirubin) and blood routine during treatment. Once a serious abnormality is found, the dosage should be adjusted or the medication should be suspended in time.
By properly monitoring and managing the risks during medication, patients can complete the entire course of treatment more safely, which also leads to a discussion on drug storage methods.
Storage methods of trabectedin
The correct storage method is the key to ensuring the stability of trabectedin's efficacy. The following content will introduce the specific requirements in detail.
Storage environment requirements
Trabectedin should be stored in a refrigerated environment with a temperature of 2°C to 8°C, avoiding freezing or exposure to direct light. It is recommended to place it in the original packaging box to reduce the influence of external factors. In addition, it is necessary to keep it dry during storage to prevent moisture from invading and causing drug deterioration.
Transportation and preparation before use
During the transportation process, appropriate insulation measures must be taken to ensure that the drug is always within the appropriate temperature range. After arriving at the destination, it should be placed in the refrigerator for refrigeration in time. Before use, it is necessary to reconstitute and dilute according to the requirements of the instructions, and strictly abide by the aseptic technical specifications to avoid potential risks.
Correct storage methods can not only extend the shelf life of trabectedin, but also maximize its therapeutic potential and provide patients with a better treatment experience.
