Fidaxomicin is approved for the treatment of Clostridium difficile-associated diarrhea in adults (18 years and older). Compared with existing drugs, Fidaxomicin has higher efficacy and lower recurrence rate in the treatment of Clostridium difficile infection (CDI).
What are the side effects of Fidaxomicin?
Fidaxomicin may cause gastrointestinal reactions, which are manifested by symptoms such as nausea, vomiting, and abdominal pain. Some patients may gradually adapt or their symptoms may be alleviated. If the symptoms continue to worsen or the patient cannot tolerate it, they should communicate with the doctor in time to adjust the treatment plan or take appropriate measures to relieve the discomfort.
Fidaxomicin may also cause gastrointestinal bleeding, manifested by symptoms such as black stools and vomiting blood, which is a manifestation of drug damage to the gastrointestinal mucosa. During the use of Fidaxomicin, patients should undergo regular blood tests to monitor changes in indicators such as hemoglobin and white blood cells.
Mechanism of action of Fidaxomicin
Fidaxomicin is a macrolide antibiotic with a novel mechanism of action. It mainly produces antibacterial effects by inhibiting bacterial RNA polymerase. The following is a detailed description of its specific mechanism of action:
Inhibition of RNA polymerase
Core function: Fidaxomicin blocks the synthesis of bacterial RNA by specifically binding to the bacterial RNA polymerase. RNA polymerase is the key enzyme responsible for transcription in bacteria. Inhibition will cause bacteria to be unable to synthesize normal proteins.
Antibacterial spectrum and sensitivity
Broad-spectrum antibacterial: Fidaxomicin has a broad-spectrum antibacterial effect and has a certain inhibitory effect on a variety of intestinal bacteria. In clinical applications, it is mainly used to treat CDAD caused by Clostridium difficile, showing a high sensitivity.
Precautions for Fidaxomicin
Precautions for Fidaxomicin have specific requirements for purchase and storage. The following is a detailed description:
Precautions for purchase
Formal channels: Patients can obtain the drug through legal overseas channels or formal medical service institutions. When purchasing, they should check the quality of the drug to avoid purchasing counterfeit and inferior products.
Understand the price: The price of Fidaxomicin may vary depending on the brand, specification and market supply. It is recommended to consult a doctor or pharmacist before purchasing to understand the approximate price range.
Storage precautions
Keep dry: Fidaxomicin should be stored in a dry environment, away from moisture and water. Humidity may cause damage to the drug or reduce its efficacy. For more information about Fidaxomicin, click for free online consultation
Appropriate temperature: Patients should avoid high and extreme temperatures when storing Fidaxomicin. The optimal storage temperature is between 15℃ and 30℃. Too high or too low temperatures may have an adverse effect on the stability and shelf life of the drug.
Warm reminder: During the use of Fidaxomicin, patients need to regularly check whether the stored Fidaxomicin is expired or deteriorated. Expired or deteriorated drugs cannot be used anymore and should be disposed of in time.
