Stiripentol(Diacomit) is a drug used to assist in the treatment of neurological seizures associated with Dravet syndrome. It is suitable for children aged 6 months and older and weighing 7 kg or more. Proper use of the drug can help control the symptoms of neurological diseases and reduce the frequency of seizures. The following content will detail the specific usage and precautions.
Instructions for use of Stiripentol(Diacomit)
The dosage of stiripentol should be calculated according to the patient's weight.
Recommended dosage and administration
The usual starting dose is 50 mg/kg per day, taken in 2-3 times. The drug should be taken with food, and avoid taking it with milk, dairy products, carbonated beverages or caffeinated beverages. Capsules or suspensions should be swallowed directly and not chewed. If the dosage form needs to be changed (such as from capsules to suspensions), it should be done under the guidance of a doctor to avoid tolerance problems caused by differences in bioavailability.
Treatment of missed doses
If a dose is missed, it should be taken as soon as possible after discovery. If it is close to the next dose, skip the missed dose and continue taking the medication as originally planned. Do not take a double dose at one time. If you miss a dose for more than 24 hours, you need to contact your doctor to adjust the subsequent medication regimen.
Strictly following the doctor's instructions is the key to controlling neurological diseases. The following content will explain the emergency treatment methods for overdose of stiripentol.
Overdose treatment methods of stiripentol
Overdose of stiripentol may cause serious adverse reactions, such as excessive sedation, ataxia, or abnormal liver function. Patients and their families need to understand the relevant symptoms and master emergency measures.
Overdose symptom identification
Common overdose symptoms include severe drowsiness, confusion, dyspnea, hypotonia, or vomiting. If the patient has the above symptoms, stop the drug immediately and monitor vital signs.
Emergency treatment measures
Immediately contact the emergency center or go to the hospital. The doctor may take gastric lavage, activated charcoal adsorption, or supportive treatment. If the patient has abnormal liver function, the transaminase level needs to be closely monitored and liver protection treatment should be performed if necessary.
Timely treatment of drug overdose can reduce health risks. The following content will explain the precautions for the use of stiripentol in special populations.
Special population use of stiripentol
The physiological state of different patient groups may affect the efficacy of the drug. The following are two groups of people who need special attention.
Guidelines for use in children
Stiripentol is only suitable for children aged 6 months and above and weighing ≥7kg. For infants under 3 years old, it needs to be used after strict evaluation and diagnosis (such as Dravet syndrome). During treatment, weight changes and neurodevelopmental conditions need to be monitored regularly. If loss of appetite or abnormal behavior occurs, the dose should be adjusted in time.
Medication recommendations for patients with hepatic and renal insufficiency
Stiripentol is contraindicated in patients with moderate or severe hepatic and renal insufficiency. Patients with mild hepatic and renal dysfunction need to use it under the guidance of a doctor and check liver enzymes and creatinine levels regularly. If symptoms such as jaundice, decreased urine volume or fatigue occur during treatment, the drug should be stopped immediately and medical treatment should be sought.
Rational use of drugs should be combined with individual health conditions, and patients and their families should maintain close communication with the medical team. Avoid adjusting the dose or combining other drugs during treatment, and regularly review liver function and blood drug concentrations. If you have any questions, please consult a professional doctor or pharmacist in time.
