Naldemedine (Symproic) is a drug used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. It works by targeting μ opioid receptors and can effectively relieve constipation symptoms without affecting the analgesic effect.
Effects and efficacy
Naldemedine is a selective peripheral μ opioid receptor antagonist specifically used to treat opioid-induced constipation (OIC). Its unique mechanism of action allows it to relieve constipation without interfering with the analgesic effect of opioids.
Mechanism of action
The main ingredient of Naldemedine is Symproic, which can specifically antagonize μ opioid receptors and block the activation of intestinal receptors by opioids, thereby restoring intestinal peristalsis and relieving constipation symptoms. Unlike traditional laxatives, Naldemedine directly targets the cause of constipation and has a more obvious effect.
Applicable population
NNaldemedinee is suitable for adult patients who use opioids for a long time, especially those with chronic non-cancer pain. For patients with cancer-related pain, if the dose of opioids is stable, it can also be considered. However, it should be noted that patients who use the drug for less than 4 weeks may not be effective.
NNaldemedinee provides a targeted solution for constipation caused by opioids, and its precise mechanism of action makes it an important choice for the treatment of OIC.
Usage and dosage
The use of Naldemedine must strictly follow the doctor's instructions. Reasonable usage and dosage are the key to confirming efficacy and reducing adverse reactions.
Recommended dose
The recommended dose for adult patients is 0.2 mg orally once a day, which can be taken with meals or on an empty stomach. There is no need to adjust the dose of opioids before taking the medicine, but if the opioid is discontinued, Naldemedine must be discontinued at the same time.
Precautions for medication
Patients should avoid adjusting the dose or stopping the medication without authorization. For patients with liver damage, those with mild or moderate damage do not need to adjust the dose, but patients with severe liver damage should avoid using it. Elderly people need to observe the reaction carefully when taking the medicine.
Correct usage and dosage are the basis for the efficacy of Naldemedine. Patients should strictly follow the doctor's instructions and make sure that the medication is safe.
Side effects and precautions
Naldemedine may cause some adverse reactions during treatment. Patients need to understand the relevant risks and take preventive measures.
Common side effects
The most common adverse reactions include abdominal pain, diarrhea, nausea and gastroenteritis, with an incidence of about 2% or more. These symptoms are usually mild, but if they persist or worsen, you need to seek medical attention in time.
Special precautions
Naldemedine may increase the risk of gastrointestinal perforation. Patients should stop taking the drug if they experience severe abdominal pain. In addition, patients with impaired blood-brain barrier may experience opioid withdrawal symptoms and need to be closely monitored. Pregnant women, breastfeeding women and children need to carefully assess the risks and benefits of medication.
Understanding side effects and precautions can help patients use Naldemedine safely, respond to possible problems in a timely manner, and clarify the treatment effect.
