Resmetirom is the world's first approved drug for the treatment of non-alcoholic steatohepatitis (NASH). The correct usage and dosage and supporting precautions are more important for efficacy and safety.
How to use Resmetirom?
The dose of Resmetirom needs to be individualized according to the patient's weight, and attention should be paid to the impact of drug interactions on the dose. Correctly mastering the medication method can maximize the efficacy and reduce potential risks.
Recommended dose and weight association
For patients with a weight of less than 100kg, 80mg orally once a day; for patients with a weight of more than 100kg, 100mg orally once a day. Drugs can be taken with or without meals. Different specifications of tablets are distinguished by surface markings (such as "P80") to facilitate patient identification.
Dosage adjustment of CYP2C8 inhibitor
Resmetirom should be avoided altogether when combined with a powerful CYP2C8 inhibitor such as geffilozi. If you need to use a medium-acting inhibitor (such as clopidogrel), the dose should be reduced to 60mg/day if you weigh less than 100kg, and the dose should be adjusted to 80 mg/day if you weigh ≥100kg. This adjustment can reduce the risk of drug accumulation due to inhibition of metabolic pathways.
Rational adjustment of the dosage can not only improve the accuracy of treatment, but also avoid safety hazards caused by drug interactions. Patients must strictly follow the doctor's instructions, regularly monitor weight changes and promptly provide feedback on drug reactions.
Precautions for Resmetirom medication
The physiological status and combined medication conditions of special populations may significantly affect the safety and effectiveness of Resmetirom. The following two types of people need special attention.
Medication guidance for special populations
Pregnant and breastfeeding women need to weigh the treatment needs and potential risks, and safety data for this population are currently lacking. Although there is no significant difference in the efficacy of elderly patients, the incidence of adverse reactions may increase and monitoring is needed. Among patients with liver and renal insufficiency, it is contraindicated for patients with decompensated cirrhosis, and dosage adjustment is not required for patients with mild to moderate renal impairment.
Drug interaction management
The metabolism of Resmetirom involves the CYP2C8 enzyme system, and the combination with specific drugs may change its blood drug concentration. In addition to CYP2C8 inhibitors, other potential interactions are recommended for consultation with medical professionals. Patients need to actively inform the current medication list to avoid using unknown drugs on their own.
The risk of treatment can be effectively reduced by systematically evaluating the individual characteristics and combined medication. The medical team needs to dynamically track the patient's status and adjust the treatment plan in a timely manner.
Contraindicated foods for patients with Resmetirom
Dietary choices may indirectly affect drug metabolism or aggravate adverse reactions. Patients should pay attention to the intake restrictions of the following two types of food during treatment.
The impact of high-fat diet
Long-term high-fat diet may aggravate the pathological progression of non-alcoholic steatohepatitis and offset the therapeutic effect of Resmetirom. It is recommended to adopt a low-fat and high-fiber diet structure and cooperate with regular exercise to jointly improve liver health.
Risks of irritating foods
Spicy or high-sugar foods may induce gastrointestinal discomfort, and may aggravate the patient's discomfort after being superimposed with common adverse reactions of Resmetirom (such as diarrhea, nausea). During the treatment period, the intake of irritating substances such as caffeine and alcohol should be reduced to maintain the stability of the digestive system.
Scientific diet management can not only improve the efficacy of drugs, but also improve the overall quality of life. Patients should formulate a personalized diet plan in accordance with the nutritionist's advice to create favorable conditions for liver repair.
