Sparsentan is clinically suitable for adult patients with primary immunoglobulin A nephropathy (IgAN). It has the title of "orphan drug" for the treatment of IgA nephropathy. Many patients and their families will be concerned about what the precautions for this drug are, and this will be introduced in detail below.
Things to note about Sparsentan
Hepatotoxicity
Patients need to monitor transaminase and total bilirubin levels monthly before starting treatment and within the first 12 months, and then check once every 3 months to prevent severe hepatotoxicity. If the patient begins to experience hepatotoxic symptoms such as nausea, vomiting, and pain in the upper right abdomen, he should stop the medication immediately and seek medical treatment. During the treatment period, when transaminase levels are abnormal, medication administration needs to be suspended and closely monitored. Only after the aminotransferase and bilirubin levels return to normal and the symptoms are relieved can you consider re-use of the medication. Patients with significantly elevated aminotransferase should avoid using sparsentan to reduce the risk of hepatotoxicity.
Embryonic-fetal toxicity
To ensure the safe use of Sparsentan in female patients, all female patients must undergo a pregnancy test before receiving treatment and confirm that the result is negative before taking the medication. During the treatment period and within one month after the withdrawal of medication, patients must undergo a monthly pregnancy test to rule out the risk of an unexpected pregnancy. For female patients with fertility, it is strongly recommended to actively take effective contraceptive measures before starting treatment, during the entire treatment period, and within one month after stopping the medication to ensure the safety of medication and avoid potential risks.
How to store Filspari?
The storage of Sparsentan should be carried out under certain conditions. The following will provide a detailed introduction on how to store Sparsentan.
Maintain the integrity of the original packaging
The drug has been carefully designed and packaged when it is shipped. It is important to maintain the integrity of the original packaging during storage to avoid damage or change the packaging method to prevent the drug from getting damp, contaminated or spoiled.
Control the storage temperature
The temperature of the drug storage environment is crucial to its quality and efficacy. According to the drug instructions, the drug should be stored in an environment of 15°C to 30°C. Too high or too low temperatures may affect the stability of the drug and reduce its efficacy. Choosing the right temperature to store the drug is the key to ensuring that the drug is safe and effective.
Ensure the environment is dry
Humidity is another factor that needs attention in drug storage. Drugs are prone to absorb moisture in the air, resulting in deterioration or reduced efficacy. When storing drugs, ensure that the environment is dry and avoid moisture. Ambient humidity can be reduced by placing a desiccant or using an airtight container.
When purchasing medicines, be sure to ensure the formality of the purchasing channels. It is recommended to choose a reputable regular pharmacy or medical institution to purchase it to ensure the quality of the medicine. Avoid purchasing drugs of unknown origin to avoid encountering counterfeit and inferior products and harming health. Choose formal channels with caution.
