Euthyrox(Levothyroxine-Natrium) Instructions:Uses,Dosage, Side Effects

Hypothyroidism: Indicated as replacement therapy in pediatric and adult patients for primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism.

TSH Suppression: Used as an adjunctive treatment to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.

General Principles: Administer orally as a single daily dose, on an empty stomach, 30 to 60 minutes before breakfast. Dosing is highly individualized based on age, body weight, cardiovascular status, and the specific condition being treated. The peak therapeutic effect may not be attained for 4 to 6 weeks.

Adult Hypothyroidism: The typical starting full replacement dose is approximately 1.6 mcg per kg per day. In elderly patients or those with underlying cardiac disease, initiate therapy at a lower dose (e.g., 12.5-25 mcg per day). The dose is adjusted in 12.5-25 mcg increments at 4-8 week intervals based on clinical response and serum TSH levels.

Pediatric Hypothyroidism: Dosing is based on body weight and age, with higher mcg/kg requirements in neonates and infants compared to older children and adolescents.

Pregnancy: Thyroid hormone requirements frequently increase during pregnancy. Serum TSH should be monitored during each trimester, and the dosage adjusted to maintain trimester-specific TSH ranges.

TSH Suppression in Thyroid Cancer: Doses are often higher than those for hypothyroidism replacement, targeting a specific level of TSH suppression, and may exceed 2 mcg per kg per day.