The recommended dosage is one 120 mg capsule taken three times daily with each main meal that contains fat. The capsule can be taken during the meal or up to one hour after eating. The dose can be omitted if a meal is missed or does not contain fat.
The therapy should be combined with a nutritionally balanced, reduced-calorie diet designed to derive approximately 30% of its calories from fat.
A daily multivitamin supplement containing fat-soluble vitamins (A, D, E, K, and beta-carotene) should be taken once daily at least 2 hours before or after XENICAL administration (e.g., at bedtime) to ensure adequate nutrition.
Specific administration guidance for concomitant medications:
Cyclosporine: Administer cyclosporine at least 3 hours after XENICAL.
Levothyroxine: Administer levothyroxine and XENICAL at least 4 hours apart. Monitor thyroid function.