Rucaparib(Rubraca)
Acetylcysteine Injection, FLUIMUCIL, Acetylcysteine InjectionAcetylcysteine Injection, FLUIMUCIL, Acetylcysteine InjectionAcetylcysteine Injection, FLUIMUCIL, Acetylcysteine Injection
Reference price:
Manufacturer:
Clovis
Formulation:
TABLET
Validity period:
24 months
Reminder: The outer packaging is for reference only, please purchase and use under the guidance of a pharmacist. For read by medical and pharmaceutical professionals only.

Rubraca is a poly (ADP-ribose) polymerase (PARP) inhibitor approved for the treatment of certain cancers associated with BRCA mutations. It works by targeting the DNA repair mechanisms of cancer cells, thereby inhibiting their ability to repair damaged DNA, leading to cell death, particularly in tumor cells. This drug is specifically indicated for patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer with deleterious BRCA mutations who have responded to prior platinum-based chemotherapy.

In addition to ovarian cancer, Rubraca has potential indications for prostate cancer treatment, though details regarding its use in this context are not explicitly mentioned in the provided specification. The primary therapeutic benefit lies in its ability to exploit synthetic lethality in tumor cells, making it a critical treatment option for patients with specific genetic profiles, particularly those with BRCA mutations.

Generic name

Rucaparib(Rubraca)
English name
Rucaparib
Alternative Names
Rubraca
Drug prices
Indications

Indicated for the maintenance treatment of BRCA-mutated recurrent ovarian cancer and BRCA-mutated metastatic castration-resistant prostate cancer.

Therapeutic Target
RUBRACA targets the enzyme poly (ADP-ribose) polymerase (PARP).
Active Ingredients
Rucaparib
Dosage form
TABLET
specifications
300mg*60 tablets*1 bottle/box
Description

RUBRACA (rucaparib) is an oral, small molecule, PARP inhibitor used in the treatment of cancers associated with BRCA mutations. By inhibiting PARP enzymes, rucaparib interferes with the repair of DNA damage in cancer cells, particularly in cells deficient in homologous recombination, such as those with BRCA mutations. This results in the accumulation of DNA damage and cancer cell death.

Rucaparib is presented in tablet form for easy oral administration.

Dosage and Administration

The recommended dose of rucaparib is 600 mg (two 300 mg tablets) taken orally twice daily, which can be administered with or without food, with a total daily dose of 1200 mg. Treatment should be continued until disease progression or unacceptable toxicity occurs.

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