Tazemetostat(TAZVERIK)
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Reference price:
Manufacturer:
Epizyme
Formulation:
TABLET
Validity period:
24 months
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TAZVERIK (tazemetostat) is an EZH2 methyltransferase inhibitor, primarily used to treat specific cancer types with EZH2 mutations, including epithelioid sarcoma and relapsed or refractory follicular lymphoma. It works by inhibiting the EZH2 enzyme, which regulates gene expression through histone methylation, a process that is often disrupted in certain cancers. This drug is FDA-approved under an accelerated approval pathway based on initial clinical data demonstrating a response to treatment. Its continued approval depends on the results of ongoing studies to confirm long-term clinical benefits.

TAZVERIK is administered orally, typically at a dose of 800 mg twice daily, and it is well-suited for patients who have already undergone prior treatments with limited options. However, patients must be monitored for potential adverse reactions, such as hematologic toxicity and lipid abnormalities, which could require dose adjustments.

Generic name

Tazemetostat(TAZVERIK)
English name
Tazemetostat
Alternative Names
TAZVERIK
Drug prices
Indications

Tazverik is indicated for the treatment of adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma who are not eligible for complete surgical resection. It is also indicated for conditions where EZH2 mutations are observed, making the drug particularly relevant in certain sarcomas and tumors linked to histone modification disruptions.

Therapeutic Target
EZH2 enzyme
Active Ingredients
The active ingredient in Tazverik is Tazemetostat, a small molecule inhibitor that selectively targets the EZH2 enzyme to modulate gene expression and exert antitumor effects.
Dosage form
TABLET
specifications
200mg*240tablets/bottle
Description
Tazverik (tazemetostat) is an oral methyltransferase inhibitor that specifically targets EZH2, an enzyme involved in the regulation of gene expression through histone methylation. By inhibiting EZH2, Tazverik exerts antineoplastic effects, making it effective in the treatment of specific sarcomas, particularly those involving mutations in EZH2. The drug has been shown to significantly reduce tumor growth and is primarily used in treating epithelioid sarcoma, a rare and aggressive cancer of soft tissue.
Dosage and Administration

The recommended dose of Tazverik is 800 mg (four 200 mg tablets) orally once daily.

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