Avalglucosidase alfa(Nexviazyme)
Acetylcysteine Injection, FLUIMUCIL, Acetylcysteine InjectionAcetylcysteine Injection, FLUIMUCIL, Acetylcysteine InjectionAcetylcysteine Injection, FLUIMUCIL, Acetylcysteine Injection
Reference price:
Manufacturer:
Sanofi
Formulation:
INJECTION
Validity period:
48 months
Reminder: The outer packaging is for reference only, please purchase and use under the guidance of a pharmacist. For read by medical and pharmaceutical professionals only.

Nexviazyme(Avalglucosidase alfa) Instructions:Uses,Dosage, Side Effects

NEXVIAZYME (avalglucosidase alfa-ngpt) is a recombinant human enzyme replacement therapy supplied as a sterile, white to pale-yellow lyophilized powder in a single-dose vial containing 100 mg. 

It is produced by Genzyme Corporation, a Sanofi company. The product must be reconstituted and diluted prior to administration as an intravenous infusion and is specifically designed to target lysosomal glycogen accumulation.

Generic name

Avalglucosidase alfa(Nexviazyme)
English name
Avalglucosidase alfa
Alternative Names
Nexviazyme
Drug prices
Indications

NEXVIAZYME is indicated for the treatment of patients 1 year of age and older with late-onset Pompe disease (lysosomal acid alpha-glucosidase [GAA] deficiency).

Therapeutic Target
Lysosomal acid alpha-glucosidase (GAA) enzyme
Active Ingredients
Avalglucosidase alfa-ngpt
Dosage form
INJECTION
specifications
100mg * 1 vial/box
Description

Molecular Weight: ~124 kDa.

Production: Synthesized in Chinese hamster ovary (CHO) cells.

Excipients: Glycine (200 mg/vial), L-histidine (10.7 mg/vial), L-histidine HCl monohydrate (6.5 mg/vial), mannitol (200 mg/vial), polysorbate 80 (1 mg/vial).

Reconstituted Solution: 10 mg/mL (pH ~6.2) after adding 10 mL Sterile Water for Injection.

Dosage and Administration

Patients ≥30 kg: 20 mg/kg every two weeks.

Patients <30 kg: 40 mg/kg every two weeks.

Administer as an intravenous infusion with incremental rate escalation. Premedication with antihistamines, antipyretics, and/or corticosteroids may be considered to reduce infusion-associated reactions.

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