ORENCIA(Abatacept) Instructions:Uses,Dosage, Side Effects

ORENCIA is indicated for the treatment of: Adults with moderately to severely active rheumatoid arthritis (RA);Pediatric patients ≥2 years of age with moderately to severely active polyarticular juvenile idiopathic arthritis (pJIA);Adults and pediatric patients ≥2 years of age with active psoriatic arthritis (PsA);Prophylaxis of acute graft-versus-host disease (aGVHD) in patients ≥2 years undergoing hematopoietic stem cell transplantation (HSCT) from a matched or 1-allele mismatched unrelated donor, in combination with a calcineurin inhibitor and methotrexate.

1. For RA and PsA (Adults, IV Use):

1.1 Administer at Weeks 0, 2, and 4, then every 4 weeks

1.2 Dosage by body weight:<60 kg: 500 mg (2 vials);60–100 kg: 750 mg (3 vials);100 kg: 1,000 mg (4 vials)

1.3 Infusion time: 30 minutes

1.4 Subcutaneous Use (RA and PsA):125 mg once weekly,IV loading dose optional for RA; not required for PsA

2. For pJIA (≥6 years, IV Use):<75 kg: 10 mg/kg;≥75 kg: Adult dosing

2.1 Administer on Days 0, 14, 28, then every 4 weeks

2.2 Subcutaneous Use (pJIA/PsA, ≥2 years):10–<25 kg: 50 mg;25–<50 kg: 87.5 mg;≥50 kg: 125 mg

2.3 Weekly administration:aGVHD Prophylaxis (IV):≥6 years: 10 mg/kg (max 1,000 mg) on Day –1, +5, +14, +28;2–<6 years: 15 mg/kg (Day –1), 12 mg/kg (Days +5, +14, +28)

2.4 Infusion time: 60 minutes