Nemolizumab(Nemluvio)
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NEMLUVIO (nemolizumab-ilto) is a monoclonal antibody designed to block the interleukin-31 receptor, playing a significant role in managing prurigo nodularis in adults. This condition, characterized by severe and persistent itching, can be debilitating for patients. NEMLUVIO® provides a targeted approach to alleviate the symptoms, improving quality of life for those affected by the condition.
NEMLUVIO is administered through subcutaneous injections, typically once every four weeks after an initial dose. The product is reconstituted before use and is delivered via a prefilled dual-chamber pen. Clinical evidence suggests that this treatment can offer significant relief from pruritus and associated skin conditions in individuals with prurigo nodularis.
Generic name
Nemolizumab(Nemluvio)
Alternative Names
Nemluvio
Indications
NEMLUVIO® is indicated for the treatment of adults with prurigo nodularis.
Therapeutic Target
NEMLUVIO® is an interleukin-31 receptor antagonist. It targets the interleukin-31 (IL-31) receptor to reduce pruritus (itching) and other symptoms associated with prurigo nodularis.
Active Ingredients
Nemolizumab
Description
NEMLUVIO (nemolizumab-ilto) for injection is a sterile, preservative-free, white lyophilized powder presented in a dual-chamber single-dose prefilled pen. One chamber contains 30 mg of nemolizumab-ilto with inactive ingredients including arginine hydrochloride (9.5 mg), poloxamer 188 (0.15 mg), sucrose (25.8 mg), trometamol (0.10 mg), and tris hydrochloride for pH adjustment. The diluent, water for injection, is located in the other chamber. After reconstitution, each prefilled pen delivers 30 mg/0.49 mL of nemolizumab-ilto at a pH range of 6.7 to 7.3.
Dosage and Administration
Adults weighing less than 90 kg:Initial dose: 60 mg (two 30 mg injections);Maintenance dose: 30 mg every 4 weeks.
Adults weighing 90 kg or more:Initial dose: 60 mg (two 30 mg injections);Maintenance dose: 60 mg every 4 weeks.
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