VANFLYTA Dosing Regimen and Administration

The recommended dosage of VANFLYTA varies by treatment phase. During induction with 7+3 chemotherapy, 35.4 mg is administered orally once daily starting on Day 8 for two weeks per cycle (Days 8-21). For consolidation with high-dose cytarabine, 35.4 mg is given orally once daily starting on Day 6 for two weeks per cycle (Days 6-19). Maintenance therapy begins with 26.5 mg orally once daily for Days 1-14 of the first cycle, increasing to 53 mg once daily from Day 15 if QTcF ≤≤ 450 ms, continued for up to 36 cycles. Tablets should be swallowed whole, with or without food, at approximately the same time each day. If a dose is missed or vomited, it should not be replaced; the next dose should be taken as scheduled.