The standard dosage for Pulmozyme (dornase alfa) is 2.5 mg (one single-dose ampule) inhaled once daily via jet or vibrating mesh nebulizer, with potential escalation to twice daily for select patients.

Recommended Administration and Nebulizer Specifications

Approved nebulizers include Hudson T Up-draft II®, PARI LC® Plus, eRapid®, and others, each requiring specific compressors or usage protocols. Pediatric patients unable to use a mouthpiece may utilize the PARI BABY™ system with a facemask. Ampules must be inspected for leaks, clarity, and integrity prior to use. Mixing Pulmozyme with other drugs in the nebulizer is contraindicated due to incompatibility risks. Dose adjustments for renal/hepatic impairment or weight-based modifications are not specified in the description.