TRUQAP (capivasertib) is administered at 400 mg orally twice daily for 4 consecutive days followed by a 3-day break, with dose adjustments for adverse reactions or drug interactions.

Dosage Regimen and Modifications

The recommended dosage of TRUQAP is 400 mg taken twice daily (approximately 12 hours apart) for 4 days, followed by a 3-day hiatus, repeated weekly. Tablets must be swallowed whole without chewing, crushing, or splitting. Dose reductions (320 mg or 200 mg twice daily) are mandated for severe adverse reactions (e.g., hyperglycemia, diarrhea) or concomitant use with CYP3A inhibitors. Missed doses within 4 hours should be taken immediately; beyond 4 hours, skip the dose. For vomiting, no replacement dose is required. Pre-/perimenopausal women require concurrent LHRH agonists. Permanent discontinuation follows intolerance after two dose reductions. Renal/hepatic impairment adjustments are not specified for severe cases.