The recommended dose is 600 mg orally, twice daily, for both NSCLC (as a single agent) and CRC (in combination with cetuximab). 

Dosage and Administration

The recommended dosage for Adagrasib is:

NSCLC: 600 mg twice daily as a single agent.

CRC: 600 mg twice daily when used with cetuximab.

Swallow the tablets whole with or without food. If vomiting occurs after a dose, do not take an additional dose; resume dosing at the next scheduled time. If a dose is missed by more than 4 hours, skip it and continue with the next scheduled dose.