Dosage and Administration of NPLATE® (Romiplostim)

For ITP patients, NPLATE® should be started at an initial dose of 1 mcg/kg once weekly via subcutaneous injection. The dose is adjusted based on platelet response, aiming for platelet counts ≥50 × 10^9/L to minimize bleeding risks. In patients exposed to radiation-induced myelosuppression (HS-ARS), the recommended dose is 10 mcg/kg as a one-time subcutaneous injection. For both groups, the treatment should be closely monitored with weekly platelet count assessments during dose adjustments and monthly once stable. If the platelet count does not increase adequately after four weeks of maximum dose, discontinue therapy.