Adverse Event Spectrum of YERVOY Therapy

YERVOY is associated with a high incidence of immune-mediated adverse reactions, including colitis, hepatitis, endocrinopathies (e.g., hypophysitis, adrenal insufficiency, thyroid dysfunction), pneumonitis, nephritis, and dermatologic reactions such as rash and pruritus. Common side effects (≥20%) include fatigue, diarrhea, rash, pruritus, nausea, musculoskeletal pain, and headache. Severe reactions may necessitate permanent discontinuation and immunosuppressive therapy. Infusion-related reactions and rare but serious complications such as myocarditis and neurological events are also reported.