The most frequent side effects of VYALEV involve infusion site issues, hallucinations, and dyskinesia, with other serious adverse reactions aligning with its warnings and precautions.

Profile of Adverse Reactions with VYALEV

The most common adverse reactions observed with VYALEV, occurring at an incidence of at least 10% and greater than oral carbidopa-levodopa, include infusion/catheter site reactions (such as erythema, pain, edema, nodule), infusion/catheter site infections (including cellulitis), hallucinations, and dyskinesia. Other significant adverse reactions, also highlighted as warnings and precautions, encompass falling asleep during daily living/somnolence, psychosis, impulse control/compulsive behaviors, withdrawal-emergent hyperpyrexia and confusion (upon rapid dose reduction or discontinuation), cardiovascular ischemic events, and potential for increased intraocular pressure in glaucoma patients. Some patients (8% for reactions, 5% for infections in Study 1) withdrew from treatment due to infusion site issues. Dose reduction or discontinuation may be considered for managing certain side effects like hallucinations or dyskinesia. The full spectrum of less common side effects is not detailed in this summary.