Symproic(Naldemedine) Side Effects

Common side effects of Naldemedine include abdominal pain, diarrhea, nausea, and gastroenteritis, with some patients potentially experiencing opioid withdrawal symptoms.

Adverse Reactions and Side Effects  

The most frequent adverse reactions to Naldemedine (Symproic) include abdominal pain, diarrhea, nausea, and gastroenteritis, occurring in more than 2% of patients. Less common but notable reactions include symptoms of opioid withdrawal, such as sweating, chills, and gastrointestinal discomfort. 

In clinical studies, these adverse effects were more common in patients taking Naldemedine compared to placebo. Patients should be monitored for any gastrointestinal disturbances or signs of opioid withdrawal. If these symptoms become severe or persistent, discontinuing the medication may be necessary. Always consult with a healthcare provider if side effects occur.