Enbrel may cause serious side effects, including infections, allergic reactions, and neurological problems.

Side Effects Title: Potential Side Effects of Enbrel

Serious side effects include infections (e.g., TB, fungal infections), allergic reactions, demyelinating nervous system disorders, and blood problems like low blood counts. Other risks include new or worsening psoriasis, heart failure, and autoimmune conditions like lupus. Common side effects include injection site reactions such as redness, itching, or swelling  .